Scarless Wound Healing

In people and domestic animals, scarring in the skin after trauma, surgery, burns or a sports injury is an important medical problem, usually resulting in unsightly aesthetics, loss of function, restriction of tissue elasticity and/or growth and adverse psychological effects.

Modern treatments are strictly empirical, unreliable and unpredictable. There are no prescription medicines for the prevention or treatment of dermal scarring. Skin wounds on early mammalian embryos cure flawlessly with no scars, whereas wounds to adult mammals are prone to scarring.

In scar treatment research, scientists are exploring the cellular and molecular differences between perfect healing in embryonic wounds and scar-forming healing in adult wounds. Relevant differences include the inflammatory response, which in embryonic wounds consists of lower quantities of less differentiated inflammatory cells. This occurrence, along with augmented levels of morphogenetic molecules involved in skin growth and morphogenesis, implies that the growth factor profile of an embryonic injury is very different from that of an adult injury.

These experiments proved the possibility of scar-less healing in the adult subject and have lead to the identification of appropriate therapeutic targets. It has been found that effective skin care highly improves or completely avoids scarring during adult injury healing in experimental animals. Some of these new drugs have satisfyingly passed safety and other tests, such that they have entered human clinical trials with approval from the appropriate regulatory authorities. Based on encouraging results from these volunteer studies, the leading drugs have now entered human patient-based tests e.g. in skin graft donor sites.

Scientific Research on Scar Treatments

The hypothesis is that evolutionary factors have been exerted on medium sized, widespread, dirty wounds with considerable tissue damage e.g. bites, bruises and contusions. Modern wounds (e.g. resulting from trauma or surgery) made by sharp objects, are recent situations not previously found in nature, in which the evolutionary selected wound healing responses are somewhat inappropriate. It has been shown that both repair with scarring and regeneration can happen within the same animal, including man, and indeed within the same tissue, thereby implying that they share similar procedures and regulators.

Consequently, by subtly altering the ratio of growth factors present in adult wound healing, we can induce adult wounds to heal flawlessly with no scars, with accelerated healing and without adverse consequences, e.g. on wound strength or wound infection rates. This implies that scarring may no longer be an inevitable consequence of modem injury or surgery, and that a completely new pharmaceutical approach to the prevention of human scarring is now possible. Not only skin suffers from scarring; they can appear in many other tissues as well.

Thus scar-improving drugs could have widespread benefits and avoid complications in several tissues, e.g. the prevention of blindness after scarring due to eye injury, support of neuronal reconnections in the peripheral and central nervous system by the elimination of glial scarring, recovery of normal gut and reproductive function by preventing strictures and adhesions after injury to the gastrointestinal or reproductive tracts, and the recovery of locomotor function by preventing scarring in tendons and ligaments.

Scars caused by wounds, burns or surgeries can now be easily eliminated. This exclusive formula is an all-natural scar treatment that will get the job done.

- Danna Finnerand